Your doctor may need to stop or delay your treatment if you experience certain side effects. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects. Call your doctor for medical advice about side effects. What Other Drugs Interact with Streptozocin? You may get some of the side effects we mention, but you are unlikely to get all of them. Anemia … A list of drugs that interact with Streptozocin. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Side Effects. Streptozocin has been found to increase the risk of developing cancer in some animals. Streptozocin is active in the L1210 leukemic mouse over a fairly wide range of parenteral dosage schedules. More: Prescribing and Technical Information. Rarely, fluorouracil can cause heart problems (including chest pain and angina), confusion and unsteadiness. Streptozocin may also be used for purposes not listed in this medication guide. Late effects include a very rare chance of a second cancer years after treatment. Streptozocin is used for cancer of the pancreas and other conditions. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea; nausea; vomiting. In 100 people receiving Streptozocin, from 4 to 20 may have: Infection, especially when white blood cell count is low. This eMedTV resource describes how certain products, such as clozapine, doxorubicin, and certain other drugs, may cause interactions with streptozocin. It is used to treat cancer of the pancreas. Seek medical attention right away if any of these SEVERE side effects occur: We also include some less common side effects. Pregnancy: FDA Pregnancy Category D. 4. You have regular tests to check your kidneys. Avoid vaccination while taking Streptozocin. It is a nitrosourea alkylating agent with selective uptake into pancreatic beta cells because of similarity to glucose in structure. 1. Allergic reactions while having streptozocin is a rare side effect. Streptozocin side effects Gastrointestinal- Diarrhea, nausea and vomiting. Streptozocin (also known as streptozotocin) is an agent with specific effects on pancreatic beta cells. Streptozocin seems to interfere with the growth of cancer cells, which are eventually destroyed. Our streptomycin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. These and others are described below. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for STREPTOZOCIN. Along with their needed effects, medicines like streptozocin can sometimes cause unwanted effects such as kidney problems and other side effects. There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). In 100 people receiving Streptozocin, more than 20 and up to 100 may have: Confusion, depression. Possible Side Effects of Streptozocin (Table Version Date: May 28, 2013) COMMON, SOME MAY BE SERIOUS. Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. These and others are described below. Streptozocin is a cancer medication that interferes with the growth and spread of cancer cells in the body. Late effects include a very rare chance of a second cancer years after treatment. You might have one or more of them. It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking Streptozocin. Drug information provided by: IBM Micromedex. Streptozocin Description: Streptozocin is an antineoplastic antibiotic produced by Streptomyces achromogenes, which is chemically similar to other nitroso Liver- Elevated liver enzyme level. It also directly affects the way the pancreas works. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Streptozocin is used to treat pancreatic cancer. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur … The effect of streptozocin on fertility in humans is not known. SLIDESHOW Digestive Disorders: Common Misconceptions … Streptozocin (84) is an N-methyl-N-nitrosourea derivative of 2-deoxyglucose that possesses cytotoxic and anticancer properties. Used in the treatment of cancer., Zanosar (streptozocin) is an antineoplastic (anticancer) medication used to treat cancer of the pancreas.Common side effects of Zanosar include: nausea; vomiting; loss of appetite; diarrhea; drowsiness; confusion; depression, or injection site reactions (swelling, redness, burning, or tenderness). Streptozocin | Interactions. This is not a complete list of side effects and others may occur. Breastfeeding. Streptozocin side effects. Streptozocin Solution, Reconstituted (Recon Soln) Side Effects by Likelihood and Severity COMMON side effects If experienced, these tend to have a Severe expression Side Effects. Nausea, vomiting. while using streptozocin. An occasional side effect of streptozocin is a change to the way your kidneys work. Rare side effects of streptozocin include: Nephrogenic diabetes insipidus; This document does not contain all possible side effects and others may occur. Source: British National Formulary - BNF - 13 August 2020. Streptozocin 1000 MG Injection [Zanosar] side effects All medicines may cause side effects, but many people have no, or minor, side effects. The combination of streptozocin and doxorubicin is superior to the current standard regimen of streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma. Streptozocin | Interactions. There isn't enough information to work out how often these side effects might happen. Along with their needed effects, medicines like streptozocin can sometimes cause unwanted effects such as kidney problems and other side effects. Streptozocin belongs to the group of medicines known as alkylating agents. You may report side effects to FDA at 1-800-FDA-1088. Other side effects. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. What are the possible side effects of streptozocin (Zanosar)? Rare side effects with capecitabine include chest pain (angina) and swollen ankles. The most common side effects of streptozocin are nausea, vomiting, decreased appetite, diarrhea, confusion, drowsiness, depression, mental state changes and problems at the site where it is injected, such as swelling, redness, pain or burning. Weekly schedule: 1,000 mg/m² once weekly; It stops the growth of cancer cells. More: Prescribing and Technical Information. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Because pancreatic beta cells have high concentrations of glucose transporter 2 (GLUT2), streptozocin is selectively toxic to these cells. Chlorozotocin alone is similar in efficacy to streptozocin plus fluorouracil, but it produces fewer gastrointestinal side e … They may not work as well or not work at all (kidney failure). Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. Since the growth of normal body cells may also be affected by streptozocin, other effects will also occur. We explain the most common side effects of this treatment here. If you are also having treatment with other cancer drugs, you may have some side effects that we have not listed here. WHY is this medicine prescribed? Very rarely you may develop a severe skin reaction. Streptozocin: Belongs to the class of alkylating agents, nitrosoureas. Talk to your doctor about the risks of receiving streptozocin. Metabolic- Decrease in sugar level. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea; feeling tired; depression; Some side effects can be serious. Streptozocin: Search drug information, interaction, images & medical diagnosis. Streptozocin may also be used for purposes not listed in this medication guide. You may report side effects to Health Canada at 1-866-234-2345. Related Links List Streptozocin Solution, Reconstituted (Recon Soln) side effects by likelihood and severity. Streptozocin may cause side effects. Tiredness OCCASIONAL, SOME MAY BE SERIOUS. Allergic reactions while having streptozocin or cisplatin is a rare side effect. Blood- Decrease in leucocytes and platelet count. Your doctor will ask you about any other medicines you are taking before prescribing streptozocin. 207 Similar to the well-known methylating agent N-methyl-N-nitrosourea (MNU), (84) decomposes in aqueous solution with release of dinitrogen, presumably via methyldiazoic acid (85) (Scheme 19). Chlorozotocin alone is similar in efficacy to streptozocin plus fluorouracil, but it produces fewer gastrointestinal side effects than the regimens containing streptozocin. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment: pain, itching, redness, swelling, blisters, or sores in … Check with your physician for additional information about side effects. Streptozocin(Zanosar) generic is an alkylating agent (chemotherapy drug), prescribed for pancreatic cancer. Streptozocin is used to treat pancreatic cancer. Streptozocin is a cancer medication that interferes with the growth and spread of cancer cells in the body. 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